Publikationen
Arbeitsgruppe PD Dr. Reiner Vogel
Biophysik, Institut für Molekulare Medizin
Universität Freiburg
2021
Fried SDE, Lewis JW, Szundi I, Martinez-Mayorga M, Mahalingam M, Vogel R, Kliger DS, Brown MF
Membrane Curvature Revisited-the Archetype of Rhodopsin Studied by Time-Resolved Electronic Spectroscopy
2020
Pope A, Sanchez-Reyes OB, South K, Zaitseva E, Ziliox M, Vogel R, Reeves PJ, Smith SO
A conserved proline hinge mediates helix dynamics and activation of rhodopsin
2016
Kimata N, Pope A, Eilers M, Opefi CA, Ziliox M, Hirshfeld A, Zaitseva E, Vogel R, Sheves M, Reeves PJ, Smith SO
Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
Nature Communications 7: 12683 PubMed URL
2011
Tarttelin EE
Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay
Cell Mol Life Sci 68: 3713-3723 PubMed URL
2010
Ye S, Zaitseva E, Caltabiano G, Schertler GFX, Sakmar TP, Deupi X, Vogel R
Tracking G protein-coupled receptor activation using genetically encoded infrared probes
Nature 464:1386-1389 PubMed URL
Zaitseva E, Brown MF, Vogel R
Sequential rearrangement of interhelical networks for rhodopsin activation in membranes: the Meta IIa conformational substate
J Am Chem Soc 132:4815-4821 PubMed URL
Zaitseva E, Saavedra M, Banerjee S, Sakmar TP, Vogel R
Surface-enhanced FTIR difference spectroscopy on a membrane protein monolayer using soluble lipoprotein particles as carriers
Biophys J 99:2327-2335 PubMed URL
Goncalves J, South K, Ahuja S, Zaitseva E, Opefi C, Eilers M, Vogel R, Reeves P, Smith SO
Highly conserved tyrosine stabilizes the active state of rhodopsin
Proc. Natl. Acad. Sci. USA 107:19861-19866 PubMed URL
2009
Ye S, Huber T, Vogel R, Sakmar TP
FTIR analysis of GPCR activation using azido probes
Nature Chem Biol 5:397-399 PubMed URL
Lüdeke S, Mahalingam M, Vogel R
Rhodopsin activation switches in a native membrane environment
Photochem Photobiol 85:437-441 PubMed URL
Schuy S, Schäfer E, Yoder NC, Kumar K, Vogel R, Janshoff A
Lipopeptides derived from HIV and SIV mimicking the prehairpin intermediate of gp41 on solid supported lipid bilayers
J Struct Biol 168:125-136 PubMed URL
Schuy S, Schäfer E, Yoder NC, Hobe S, Kumar K, Vogel R, Janshoff A
Coiled-coil lipopeptides mimicking the prehairpin intermediate of glycoprotein gp41
Angew Chem Int Ed 48: 751-754 PubMed URL
2008
Mahalingam M, Martinez-Mayorga K, Brown MF, Vogel R
Two protonation switches control rhodopsin activation in membranes
Proc. Natl. Acad. Sci. USA 105: 17795-17800 PubMed URL
Jiang X, Zaitseva E, Schmidt M, Engelhard M, Siebert F, Schlesinger R, Ataka K, Vogel R, Heberle J
Resolving
voltage-dependent structural changes of a membrane photoreceptor
Proc. Natl. Acad. Sci. USA 105:12113-12117 PubMed URL
Schuy S, Faiss S, Yoder NC, Kalsani V, Kumar K, Janshoff A, Vogel R
Structure and thermotropic phase behavior of fluorinated phospholipid bilayers: A combined attenuated total reflection IR spectroscopy and imaging ellipsometry study
J Phys Chem B 112: 8250-8256 PubMed URL
Standfuss J, Zaitseva E, Mahalingam M, Vogel R
Structural impact of the E113Q counterion mutation on the activation and deactivation pathways of the G protein-coupled receptor rhodopsin
J Mol Biol 380: 145-157 PubMed URL
Vogel R, Mahalingam M, Lüdeke S, Huber T, Siebert F, Sakmar TP
Functional role of the “ionic lock” – an interhelical hydrogen bond network in family A heptahelical receptors
J Mol Biol 380: 648-655 PubMed URL
2007
Bartl F, Vogel R
Structural and functional properties of Metarhodopsin III: Recent spectroscopic studies on deactivation pathways of rhodopsin
Phys Chem Chem Phys 9: 1648 - 1658 PubMed URL
Vogel R, Martell S, Mahalingam M, Engelhard M, Siebert F
Interaction of a G protein-coupled receptor with a G protein-derived peptide induces structural changes in both peptide and receptor:
A Fourier-transform infrared study using isotopically labeled peptides
J Mol Biol 366: 1580-1588 PubMed URL
Vogel R, Sakmar TP, Sheves M, Siebert F
Coupling of protonation switches during rhodopsin activation
Photochem Photobiol 83: 286-292 PubMed URL
Yoder NC, Kalsani V, Schuy S, Vogel R, Janshoff A, Kumar K
Nanoscale patterning in mixed fluorocarbon/hydrocarbon phospholipid bilayers
J Am Chem Soc 129: 9037 - 9043 PubMed URL
2006
Mahalingam M, Vogel R
The all-trans 15-syn retinal chromophore of Metarhodopsin III is a partial agonist and not an inverse agonist
Biochemistry 45: 15624-15632 PubMed URL
Vogel R, Siebert F, Yan ECY, Sakmar TP, Hirshfeld A, Sheves M
Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff base
J Am Chem Soc 128: 10503-10512 PubMed URL
Lüdeke S, Lorenz-Fonfria V, Siebert F, Vogel R
Time-resolved rapid-scan FTIR difference spectroscopy on a non-cyclic photosystem: rhodopsin photointermediates from Lumi to Meta II
Biopolymers 83: 159-169 PubMed URL
Vogel R, Lüdeke S, Siebert F, Sakmar TP, Hirshfeld A, Sheves M
Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation
Biochemistry 45:1640-1652 PubMed URL
2005
Lüdeke S, Beck M, Yan EC, Sakmar TP, Siebert F, Vogel R
The role of Glu 181 in the photoactivation of rhodopsin
J Mol Biol 353: 345-356 PubMed URL
Vogel R, Lüdeke S, Siebert F, Hirshfeld A, Sheves M
Agonists and partial agonists of rhodopsin: retinals with ring modifications
Biochemistry 44: 11684-11699 PubMed URL
2004
Ruprecht J, Mielke T, Vogel R, Villa C, Schertler GFX
Electron crystallography reveals the structure of Metarhodopsin I
EMBO J 23: 3609-3620 PubMed URL
Vogel R, Lüdeke S, Radu I, Siebert F, Sheves M
Photoreactions of Metarhodopsin III
Biochemistry 43: 10255-10264 PubMed URL
Vogel R, Siebert F, Zhang XY, Fan GB, Sheves M
Formation of Meta III during the decay of activated rhodopsin proceeds via Meta I and not via Meta II
Biochemistry 43: 9457-9466 PubMed URL
Vogel R
Influence of salts on rhodopsin photoproduct equilibria and protein stability
Curr Opin Colloid Interf Sci 9: 133-138 URL
Vogel R, Ruprecht J, Villa C, Mielke T, Schertler GFX, Siebert F
Rhodopsin photoproducts in 2D crystals
J Mol Biol 338:597-609 PubMed URL
2003
Vogel R, Siebert F, Mathias G, Tavan P, Fan GB, and Sheves M
Deactivation of rhodopsin in the transition from the signaling state Meta II to Meta III involves a thermal isomerization of the retinal chromophore C=N double bond
Biochemistry 42: 9863-9874 PubMed URL
Vogel R, Siebert F
Fourier transform infrared spectroscopy study for new insights into molecular properties and activation mechanisms of visual pigment rhodopsin
Biospectroscopy 72: 133-148 PubMed URL
2002
Fan GB, Siebert F, Sheves M, Vogel R
Rhodopsin with 11-cis-locked chromophore is capable of forming an active state photoproduct
J Biol Chem 277: 40229-40234 PubMed URL
Vogel R, Fan GB, Lüdeke S, Siebert F, Sheves M
A non-bleachable rhodopsin analogue with a slow photocycle
J Biol Chem 277: 40222-40228 PubMed URL
Vogel R, Siebert F
Conformation and stability of alpha-helical membrane proteins: I. Influence of salts on conformational equilibria between active and inactive states of rhodopsin
Biochemistry 41: 3529-3535 PubMed URL
Vogel R, Siebert F
Conformation and stability of alpha-helical membrane Proteins: II. Influence of pH and salts on stability and unfolding of rhodopsin
Biochemistry 41: 3536-3445 PubMed URL
2001
Vogel R, Siebert F
Conformations of the active and the inactive states of opsin
J Biol Chem 276: 38487-38493 PubMed URL
Vogel R, Fan GB, Siebert F, Sheves M
Anions specifically stabilize a Metarhodopsin II-like photoproduct with a protonated Schiff base
Biochemistry 40: 13342-13352 PubMed URL
Vogel R, Fan GB, Sheves M, Siebert F
Salt Dependence of the formation and stability of the signaling state in G protein-coupled receptors: Evidence for the involvement of the Hofmeister effect
Biochemistry 40: 483-493 PubMed URL
2000
Vogel R, Siebert F
Vibrational spectroscopy as a tool for probing protein function
Curr Opin Chem Biol 4: 518-523 PubMed URL
Kiefer H, Vogel R, Maier K
Bacterial expression of G-protein coupled receptors: Prediction of expression levels from sequence
Receptors Channels 7: 109-119 PubMed URL
Vogel R, Fan GB, Sheves M, Siebert F
The molecular origin of the inhibition of transducin activation in rhodopsin lacking the 9-methyl group of the retinal chromophore: A UV-vis and FTIR spectroscopic study
Biochemistry 39: 8895-8908 PubMed URL
1999
Kiefer H, Maier K, Vogel R
Refolding of G protein-coupled receptors from inclusion bodies produced in E.coli
Biochem Soc Trans 27: 908-912 PubMed
Vogel R, Süssmuth R
A model for the generation of low level chemiluminescence from microbiological growth media and its depletion by bacterial cells
Bioelectrochem Bioenerg 48: 375-383 PubMed URL
Vogel R, Süssmuth R
Low level chemiluminescence from liquid culture media
J Appl Microbiol 86: 999-1007 PubMed URL
Vogel R, Süssmuth R
Weak light emission patterns from lactic acid bacteria
Luminescence 14: 99-105 PubMed URL
1998
Vogel R, Süssmuth R
Involvement of the cell membrane in chemiluminescence patterns from bacterial cultures
Bioelectrochem Bioenerg 46: 65-69 URL
Vogel R, Guo X, Süssmuth R
Chemiluminescence patterns from bacterial cultures undergoing bacteriophage-induced mass lysis
Bioelectrochem Bioenerg 46: 59-64 URL
Vogel R, Süssmuth R
Interaction of bacterial cells with weak light emission from culture media
Bioelectrochem Bioenerg 45: 93-101 URL
1995
Sokolov IM, Vogel R, Alemany PA, Blumen A
Continuous-time random walk of a rigid triangle
J
Phys A 28: 6645-6653
URL
1994
Alemany PA, Vogel R, Sokolov IM, Blumen A
A dumbbell's random walk in continuous time
J Phys A 27: 7733-7738 (1994) URL